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Research is on the structure and function of intercellular junctions, especially in the tissues of arthropods and urochordates. Particular attention has been paid to the intramembranous assembly of these as visualised in freeze-fracture replicas. Tight and gap junctions, as well as septate junctions, this last type unique to the invertebrates have been analysed in this way and the lateral migration of junctional IMPs intramembranous particles into functional macular plaques or linear arrays has been observed and documented. Deep-etching investigations are clarifying the mechanisms of the underlying cytoskeletal attachments to junctional membrane components. This research is in collaboration with Italian colleagues as is that on the embryonic development of ascidian neural ganglion gland.
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